Article
Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder.
American journal of medical genetics - 12 Jun 2000
Hamilton S P, Haghighi F, Heiman G A, Klein D F, Hodge S E, Fyer A J, Weissman M M, Knowles J A
Abstract excerpt
Clinical and animal studies suggest a role for the neurotransmitter dopamine in anxiety states. In humans, one such condition is panic disorder, which is typified by recurrent panic attacks accompanied by anticipatory anxiety. Family, segregation, and twin studies imply a genetic component to the pathophysiology of panic disorder. In this study, we examined the genes for the D4 dopamine receptor (DRD4) and the...
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