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Article

Increased expression of clumping factor and fibronectin-binding proteins by hemB mutants of Staphylococcus aureus expressing small colony variant phenotypes.

Infection and immunity - 1 Oct 2002

Vaudaux Pierre, Francois Patrice, Bisognano Carmelo, Kelley William L, Lew Daniel P, Schrenzel Jacques, Proctor Richard A, McNamara Peter J, Peters G, Von Eiff Christof

Abstract excerpt

Small colony variants (SCVs) of Staphylococcus aureus are slow-growing subpopulations that cause persistent and relapsing infections. The altered phenotype of SCV can arise from defects in menadione or hemin biosynthesis, which disrupt the electron transport chain and decrease ATP concentrations. With SCVs, virulence is altered by a decrease in exotoxin production and susceptibility to various antibiotics,...

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Identifiers

PMID: 12228267
DOI: 10.1128/IAI.70.10.5428-5437.2002
PMCID: PMC128368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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