B cell responses to a peptide epitope. II: Multiple levels of selection during maturation of primary responses.

doi:10.1038/icb.1997.38

Article

B cell responses to a peptide epitope. II: Multiple levels of selection during maturation of primary responses.

Immunology and cell biology - 1 Jun 1997

Tuteja R, Agarwal A, Vijayakrishnan L, Nayak B P, Gupta S K, Kumar V, Rao K V

Abstract excerpt

This report analyses murine primary humoral recognition of a linear domain (MEP 17-31) within a 100 amino acid polypeptide, MEP-1. An analysis of the early primary IgM response revealed that MEP 17-31 presented at least two distinct domains for pre-immune B cell recognition represented by MEP-1 residues 19-23 and 26-28. However, subsequent maturation into an IgG response saw an exclusive selection for the...

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B cell responses to a peptide epitope. II: Multiple levels of selection during maturation of primary responses.

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