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Article

Mutational analysis of copper binding by human tyrosinase.

The Journal of investigative dermatology - 1 Aug 1997

Spritz R A, Ho L, Furumura M, Hearing V J

Abstract excerpt

Tyrosinase (EC 1.14.18.1) is a copper-containing enzyme that catalyzes several reactions in the biosynthesis of melanin pigments and is deficient in patients with type I oculocutaneous albinism (OCA1). Tyrosinase is thought to bind two copper ions, one at each of two conserved sequence motifs, termed CuA and CuB, but to date this has been directly proved only for the Neurospora and mushroom enzyme. Here, we...

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Identifiers

PMID: 9242509
DOI: 10.1111/1523-1747.ep12319351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational analysis of copper binding by human tyrosinase.PMID 9242509Read ↗

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