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Article

Mutational analysis of copper binding by human tyrosinase.

The Journal of investigative dermatology - 1 Aug 1997

Spritz R A, Ho L, Furumura M, Hearing V J

Abstract excerpt

Tyrosinase (EC 1.14.18.1) is a copper-containing enzyme that catalyzes several reactions in the biosynthesis of melanin pigments and is deficient in patients with type I oculocutaneous albinism (OCA1). Tyrosinase is thought to bind two copper ions, one at each of two conserved sequence motifs, te...

Topics

Conserved Sequence
Copper
DNA Mutational Analysis
Histidine
Humans
Monophenol Monooxygenase
Mutation
Protein Binding

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9242509
DOI: 10.1111/1523-1747.ep12319351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9242509-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutational analysis of copper binding by human tyrosinase.PMID 9242509Read ↗

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