Classical lissencephaly and double cortex (subcortical band heterotopia): LIS1 and doublecortin.

Abstract excerpt

Classical lissencephaly and double cortex are genetic neuronal migration disorders associated with mental retardation and epilepsy. In classical lissencephaly, the six-layered cortex is replaced by a four layered structure lacking normal gyri or sulci. In double cortex, a second layer of cortical neurons underlies a normal cortex. A mutation in LIS1 or doublecortin can lead to either classical lissencephaly or...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 1-Alkyl-2-acetylglycerophosphocholine Esterase
• Share to Congenital Abnormalities