Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs230

1 Aug 1997

Abstract excerpt

Antibodies to the sexual-stage surface antigens of Plasmodium falciparum, Pfs230 and Pfs48/45, can abolish the infectivity of gametes to mosquitoes; these antigens have been proposed as candidates for inclusion in a malaria transmission-blocking vaccine. One possible mechanism of antibody-mediated transmission blocking is complement-mediated gamete lysis. We have used a panel of human sera from geographically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Invertebrate Immune Response Mechanisms
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9234748
DOI: 10.1128/iai.65.8.3017-3023.1997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs230PMID 9234748Read ↗

Malaria transmission‐blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst productionSemantic proximity Read ↗

Transmission‐blocking antibodies against multiple, non‐variant target epitopes of the <i>Plasmodium falciparum</i> gamete surface antigen Pfs230 are all complement‐fixingSemantic proximity Read ↗

IgM plays a prominent role in naturally acquired immunity against <i>Plasmodium falciparum</i> gametocytesSemantic proximity Read ↗

Transmission-blocking immunity to <i>Plasmodium falciparum</i> in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230Semantic proximity Read ↗

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametesSemantic proximity Read ↗

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoesSemantic proximity Read ↗

N-Terminal Prodomain of Pfs230 Synthesized Using a Cell-Free System Is Sufficient To Induce Complement-Dependent Malaria Transmission-Blocking ActivitySemantic proximity Read ↗

Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibodySemantic proximity Read ↗

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in childrenSemantic proximity Read ↗

Pfs48/45 nanobodies block <i>Plasmodium falciparum</i> transmissionSemantic proximity Read ↗

Reversible host cell surface remodelling limits immune recognition and maximizes transmission of <i>Plasmodium falciparum</i> gametocytesSemantic proximity Read ↗

Induction and Kinetics of Complement-Fixing Antibodies Against Plasmodium vivax Merozoite Surface Protein 3α and Relationship With Immunoglobulin G Subclasses and Immunoglobulin MSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.