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Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

27 Apr 2018

Abstract excerpt

BACKGROUND: Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constraint in developing highly efficacious vaccines, as we lack strong correlates of protective immunity. METHODS: We quantified the ability of human antibodies from malaria-exposed populations to...

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PMID: 29706136
DOI: 10.1186/s12916-018-1054-2

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