Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

doi:10.1128/mcb.15.10.5258

Article

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

1 Oct 1995

Abstract excerpt

Interleukin 12 (IL-12) is an inducible cytokine composed of 35- and 40-kDa subunits that is critical for promoting T helper type 1 development and cell-mediated immunity against pathogens. The 40-kDa subunit, expressed by activated macrophages and B cells, is induced by several pathogens in vivo and in vitro and is augmented or inhibited by gamma interferon (IFN-gamma) or IL-10, respectively. Control of IL-12 p40...

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