Truncation mutations in the transactivation region of PAX6 result in dominant-negative mutants.

doi:10.1074/jbc.273.34.21531

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Article

Truncation mutations in the transactivation region of PAX6 result in dominant-negative mutants.

The Journal of biological chemistry - 21 Aug 1998

Singh S, Tang H K, Lee J Y, Saunders G F

Abstract excerpt

PAX6 is a transcription factor with two DNA-binding domains (paired box and homeobox) and a proline-serine-threonine (PST)-rich transactivation domain. PAX6 regulates eye development in animals ranging from jellyfish to Drosophila to humans. Heterozygous mutations in the human PAX6 gene result in...

Topics

3T3 Cells
Animals
Binding Sites
Cell Line
DNA
DNA-Binding Proteins
Eye Proteins
Homeodomain Proteins
Humans
Mice
Mutation
PAX6 Transcription Factor
Paired Box Transcription Factors
Repressor Proteins
Transcriptional Activation

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