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Article

A new look at an old virus: patterns of mutation accumulation in the human H1N1 influenza virus since 1918.

Theoretical biology & medical modelling - 12 Oct 2012

Carter Robert W, Sanford John C

Abstract excerpt

BACKGROUND: The H1N1 influenza A virus has been circulating in the human population for over 95 years, first manifesting itself in the pandemic of 1917-1918. Initial mortality was extremely high, but dropped exponentially over time. Influenza viruses have high mutation rates, and H1N1 has undergone significant genetic changes since 1918. The exact nature of H1N1 mutation accumulation over time has not been fully...

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Identifiers

PMID: 23062055
DOI: 10.1186/1742-4682-9-42
PMCID: PMC3507676

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