Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Point mutations within and outside the homeodomain identify sequences required for proboscipedia homeotic function in Drosophila.

Genetics - 1 Jul 1997

Benassayag C, Boube M, Seroude L, Cribbs D L

Abstract excerpt

The Drosophila homeotic gene proboscipedia (pb) encodes a homeodomain protein homologous to vertebrate HoxA2/B2 required for adult mouthparts formation. A transgenic Hsp70-pb (HSPB) element that rescues pb mutations also induces the dominant transformation of antennae to maxillary palps. To identify sequences essential to PB protein function, we screened for EMS-induced HSPB mutations leading to phenotypic...

Topics

Amino Acid Sequence
Animals
Binding Sites
Conserved Sequence
Drosophila
Drosophila Proteins
Female
Homeodomain Proteins
Insect Proteins
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Point Mutation

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 9215898
DOI: 10.1093/genetics/146.3.939
PMCID: PMC1208062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9215898-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Point mutations within and outside the homeodomain identify sequences required for proboscipedia homeotic function in Drosophila.PMID 9215898Read ↗

Structural complexity and evolutionary conservation of the Drosophila homeotic gene proboscipedia.Semantic proximity Read ↗

Analysis of Drosophila proboscipedia mutant alleles.Semantic proximity Read ↗

A functional analysis of 5', intronic and promoter regions of the homeotic gene proboscipedia in Drosophila melanogaster.Semantic proximity Read ↗

HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.Semantic proximity Read ↗

In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster.Semantic proximity Read ↗

Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo.Semantic proximity Read ↗

Ectopic expression of the Drosophila homeotic gene proboscipedia under Antennapedia P1 control causes dominant thoracic defects.Semantic proximity Read ↗

Phenogenetics of the homeotic mutant proboscipedia in Aedes albopictus.Semantic proximity Read ↗

The Drosophila homeotic mutation Nasobemia (AntpNs) and its revertants: an analysis of mutational reversion.Semantic proximity Read ↗

Homeotic genes of Drosophila.Semantic proximity Read ↗

Physical localization of the mesoderm development (mesd) functional region.Semantic proximity Read ↗

Homeotic proboscipedia cell identity functions respond to cell signaling pathways along the proximo-distal axis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.