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Article

Point mutations within and outside the homeodomain identify sequences required for proboscipedia homeotic function in Drosophila.

Genetics - 1 Jul 1997

Benassayag C, Boube M, Seroude L, Cribbs D L

Abstract excerpt

The Drosophila homeotic gene proboscipedia (pb) encodes a homeodomain protein homologous to vertebrate HoxA2/B2 required for adult mouthparts formation. A transgenic Hsp70-pb (HSPB) element that rescues pb mutations also induces the dominant transformation of antennae to maxillary palps. To identify sequences essential to PB protein function, we screened for EMS-induced HSPB mutations leading to phenotypic...

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Identifiers

PMID: 9215898
DOI: 10.1093/genetics/146.3.939
PMCID: PMC1208062

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