Article
Silent chromatin determines target preference of the Saccharomyces retrotransposon Ty5.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997
Zou S, Voytas D F
Abstract excerpt
The HML and HMR mating loci of Saccharomyces cerevisiae are bound in silent chromatin, which is assembled at the flanking E and I transcriptional silencers. The retrotransposon Ty5 preferentially integrates into regions of silent chromatin, and Ty5 insertions near the HMR-E silencer account for approximately 2% of total transposition events. Most Ty5 insertions occur within 800 bp on either side of the...
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