Article
Yin and Yang of histone H2B roles in silencing and longevity: a tale of two arginines.
Genetics - 1 Nov 2010
Dai Junbiao, Hyland Edel M, Norris Anne, Boeke Jef D
Abstract excerpt
In budding yeast, silent chromatin is defined at the region of telomeres, rDNA loci, and silent mating loci. Although the silent chromatin at different loci shows structural similarity, the underlying mechanism to establish, maintain, and inherit these structures may be fundamentally different. In this study, we found two arginine residues within histone H2B, which are specifically required to maintain either the...
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