Article
Characterization of a receptor for interleukin 5 on human eosinophils: variable expression and induction by granulocyte/macrophage colony-stimulating factor.
The Journal of experimental medicine - 1 Nov 1990
Chihara J, Plumas J, Gruart V, Tavernier J, Prin L, Capron A, Capron M
Abstract excerpt
Interleukin 5 (IL-5) acts on eosinophil differentiation and activation, suggesting the existence of a membrane receptor for IL-5 on eosinophils. Here, we report that 125I-labeled recombinant human IL-5 bound, at 4 degrees C, to high affinity receptors on human eosinophils. The association constan...
Topics
- Cells, Cultured
- Eosinophils
- Gene Expression Regulation
- Genetic Variation
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Interleukin-3
- Interleukin-5
- Receptors, Immunologic
- Receptors, Interleukin
- Receptors, Interleukin-5
- Recombinant Proteins