Article
Multiple endocrine neoplasia type 2: 2007 update.
Hormone research - 1 Jan 2007
Raue Friedhelm, Frank-Raue Karin
Abstract excerpt
BACKGROUND: Multiple endocrine neoplasia type 2 (MEN-2) is an autosomal dominant tumour syndrome caused by germline-activating mutations of the RET proto-oncogene. It is clinically characterised by the presence of medullary thyroid carcinoma (MTC), bilateral pheochromocytoma and primary hyperparathyroidism (MEN-2A) within a single patient. Three distinct clinical forms have been described depending on the...
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