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Article

Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPL(S447X) beneficial mutation.

Human gene therapy - 1 Sept 2004

Ross Colin J D, Twisk Jaap, Meulenberg Janneke M, Liu Guoqing, van den Oever Karin, Moraal Ewoud, Hermens Wim T, Rip Jaap, Kastelein John J P, Kuivenhoven Jan Albert, Hayden Michael R

Abstract excerpt

Human lipoprotein lipase (LPL) deficiency causes profound hypertriglyceridemia and life-threatening pancreatitis. We recently developed an adult murine model for LPL deficiency: LPL -/- mice display grossly elevated plasma triglyceride (TG) levels (>200-fold) and very low high-density lipoprotein...

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Source

Identifiers

PMID: 15353045
DOI: 10.1089/hum.2004.15.906

Genes

LPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15353045-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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