Article
Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum.
The Journal of biological chemistry - 4 Jul 1997
Haynes R L, Zheng T, Nicchitta C V
Abstract excerpt
To investigate the role of protein folding and chaperone-nascent chain interactions in translocation across the endoplasmic reticulum membrane, the translocation of wild type and mutant forms of preprolactin were studied in vivo and in vitro. The preprolactin mutant studied contains an 18-amino acid substitution at the amino terminus of the mature protein, eliminating a disulfide-bonded loop domain. In COS-7...
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