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Article

Role of a pro-sequence in the secretory pathway of prothyrotropin-releasing hormone.

The Journal of biological chemistry - 14 Nov 2008

Romero Amparo, Cakir Isin, Vaslet Charles A, Stuart Ronald C, Lansari Omar, Lucero Hector A, Nillni Eduardo A

Abstract excerpt

The biogenesis of rat thyrotropin releasing hormone (TRH) involves the processing of its precursor (proTRH) into five biologically active TRH peptides and several non-TRH peptides where two of them had been attributed potential biological functions. This process implicates 1) proper folding of proTRH in the endoplasmic reticulum after its biosynthesis and exit to the Golgi apparatus and beyond, 2) initial...

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Identifiers

PMID: 18779326
DOI: 10.1074/jbc.M803413200
PMCID: PMC2581549

Genes

TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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