Article
Signal sequence processing in rough microsomes.
The Journal of biological chemistry - 25 Aug 1995
Lyko F, Martoglio B, Jungnickel B, Rapoport T A, Dobberstein B
Abstract excerpt
Secretory proteins are synthesized with a signal sequence that is usually cleaved from the nascent protein during the translocation of the polypeptide chain into the lumen of the endoplasmic reticulum. To determine the fate of a cleaved signal sequence, we used a synchronized in vitro translocati...
Topics
- Amino Acid Sequence
- Animals
- Cytosol
- Dogs
- In Vitro Techniques
- Kinetics
- Microsomes
- Molecular Sequence Data
- Mutation
- Pancreas
- Peptide Fragments
- Prolactin
- Protein Precursors
- Protein Processing, Post-Translational
- Protein Sorting Signals