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Article

Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 1997

Guo R, Quarles L D

Abstract excerpt

Inactivating mutations of the neutral endopeptidase, PEX, have been identified as the cause of X-linked hypophosphatemia (XLH). Though the function of PEX is unknown, current information suggests that impaired renal phosphate conservation in XLH is due to the failure of PEX to either degrade an undefined phosphaturic factor or activate a novel phosphate-conserving hormone. The physiologically relevant target...

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Identifiers

PMID: 9199999
DOI: 10.1359/jbmr.1997.12.7.1009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts.PMID 9199999Read ↗

Pex mRNA Is Localized in Developing Mouse Osteoblasts and OdontoblastsSemantic proximity Read ↗

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.Semantic proximity Read ↗

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The PEX gene: its role in X-linked rickets, osteomalacia, and bone mineral metabolism.Semantic proximity Read ↗

X-linked hypophosphataemia: a homologous disorder in humans and mice.Semantic proximity Read ↗

Coordinated maturational regulation of PHEX and renal phosphate transport inhibitory activity: evidence for the pathophysiological role of PHEX in X-linked hypophosphatemia.Semantic proximity Read ↗

Evidence for Phex haploinsufficiency in murine X-linked hypophosphatemia.Semantic proximity Read ↗

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.Semantic proximity Read ↗

1,25-(OH)2D3 down-regulates expression of Phex, a marker of the mature osteoblast.Semantic proximity Read ↗

Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets.Semantic proximity Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

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