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Article

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.

15 Mar 1997

Abstract excerpt

PEX, a phosphate-regulating gene with homology to endopeptidases on the X chromosome, was recently identified as the candidate gene for X-linked hypophosphatemia. In the present study, we cloned mouse and human Pex/PEX cDNAs encoding part of the 5' untranslated region, the protein coding region, and the entire 3' untranslated region, determined the tissue distribution of Pex/PEX mRNA, and characterized the Pex...

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Identifiers

PMID: 9077527
DOI: 10.1172/jci119276

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.PMID 9077527Read ↗

Evidence for Phex haploinsufficiency in murine X-linked hypophosphatemia.Semantic proximity Read ↗

Pex mRNA Is Localized in Developing Mouse Osteoblasts and OdontoblastsSemantic proximity Read ↗

Developmental Expression and Tissue Distribution of Phex Protein: Effect of the <i>Hyp</i> Mutation and Relationship to Bone MarkersSemantic proximity Read ↗

Pex Gene Deletions in Gy and Hyp Mice Provide Mouse Models for X-Linked HypophosphatemiaSemantic proximity Read ↗

Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts.Semantic proximity Read ↗

Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets.Semantic proximity Read ↗

Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter.Semantic proximity Read ↗

X-linked hypophosphataemia: a homologous disorder in humans and mice.Semantic proximity Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

The PEX gene: its role in X-linked rickets, osteomalacia, and bone mineral metabolism.Semantic proximity Read ↗

Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.Semantic proximity Read ↗

Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport.Semantic proximity Read ↗

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