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Article

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.

American journal of physiology. Endocrinology and metabolism - 1 Jul 2003

Quarles L Darryl

Abstract excerpt

There is evidence for a hormone/enzyme/extracellular matrix protein cascade involving fibroblastic growth factor 23 (FGF23), a phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX), and a matrix extracellular phosphoglycoprotein (MEPE) that regulates systemic phosphate homeostasis and mineralization. Genetic studies of autosomal dominant hypophosphatemic rickets (ADHR) and...

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Share to Calcification, Physiologic
Share to Extracellular Matrix Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12791601
DOI: 10.1152/ajpendo.00016.2003

Genes

FGF23
MEPE
PHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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