Article
Role of bacterial Mn-cofactored superoxide dismutase in oxidative stress responses, nasopharyngeal colonization, and sustained bacteremia caused by Haemophilus influenzae type b.
Infection and immunity - 1 Jul 1997
D'Mello R A, Langford P R, Kroll J S
Abstract excerpt
Haemophilus influenzae type b, a causative agent of bacterial sepsis and meningitis in young children, contains a single superoxide dismutase (SOD), a cytoplasmic MnSOD. To study the role of this enzyme, a chromosomal sodA::lacZ mutant (M-2) was constructed. M-2 had an increased sensitivity towar...
Topics
- Animals
- Bacteremia
- Haemophilus Infections
- Haemophilus influenzae
- Mutation
- Nose
- Oxidative Stress
- Pharynx
- Rats
- Superoxide Dismutase
- Virulence