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Article

HIV-1 induces telomerase activity in monocyte-derived macrophages, possibly safeguarding one of its reservoirs.

Journal of virology - 1 Oct 2012

Reynoso Rita, Wieser Matthias, Ojeda Diego, Bönisch Maximilian, Kühnel Harald, Bolcic Federico, Quendler Heribert, Grillari Johannes, Grillari-Voglauer Regina, Quarleri Jorge

Abstract excerpt

Monocyte-derived macrophages (MDM) are widely distributed in all tissues and organs, including the central nervous system, where they represent the main part of HIV-infected cells. In contrast to activated CD4(+) T lymphocytes, MDM are resistant to cytopathic effects and survive HIV infection for a long period of time. The molecular mechanisms of how HIV is able to persist in macrophages are not fully elucidated...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Interleukin-4

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Source

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Identifiers

PMID: 22787205
DOI: 10.1128/JVI.01495-12
PMCID: PMC3457250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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