Article
Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia.
Journal of medical genetics - 1 Jun 1997
Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T
Abstract excerpt
A common missense mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, a C to T substitution at nucleotide 677, is responsible for reduced MTHFR activity and associated with modestly increased plasma homocysteine concentrations. Since underlying maternal vascular disease increases the risk of pre-eclampsia, we had the working hypothesis that pre-eclampsia patients would have an increased T677 allele...
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