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Article

Chaperone-mediated autophagy degrades mutant p53.

Genes & development - 1 Aug 2013

Vakifahmetoglu-Norberg Helin, Kim Minsu, Xia Hong-Guang, Iwanicki Marcin P, Ofengeim Dimitry, Coloff Jonathan L, Pan Lifeng, Ince Tan A, Kroemer Guido, Brugge Joan S, Yuan Junying

Abstract excerpt

Missense mutations in the gene TP53, which encodes p53, one of the most important tumor suppressors, are common in human cancers. Accumulated mutant p53 proteins are known to actively contribute to tumor development and metastasis. Thus, promoting the removal of mutant p53 proteins in cancer cell...

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Identifiers

PMID: 23913924
DOI: 10.1101/gad.220897.113
PMCID: PMC3744729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23913924-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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