Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

Cancer research - 1 Jun 1997

Pietsch T, Waha A, Koch A, Kraus J, Albrecht S, Tonn J, Sörensen N, Berthold F, Henk B, Schmandt N, Wolf H K, von Deimling A, Wainwright B, Chenevix-Trench G, Wiestler O D, Wicking C

Abstract excerpt

Inactivating mutations in the PTCH gene, a human homologue of the Drosophila segment polarity gene patched, have been identified recently in patients with nevoid basal cell carcinoma syndrome. These patients are predisposed to various neoplasias including basal cell carcinomas and medulloblastomas (MBs). To determine the involvement of PTCH in sporadic MBs, which represent the most frequent malignant brain tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Infant
Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Genetic Variation

Share to Membrane Proteins

Share to Mutation

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 9187099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.PMID 9187099Read ↗

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.Semantic proximity Read ↗

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours.Semantic proximity Read ↗

Identification of PATCHED mutations in medulloblastomas by direct sequencing.Semantic proximity Read ↗

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.Semantic proximity Read ↗

Mutations in the human homologue of the Drosophila patched gene in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.Semantic proximity Read ↗

Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident.Semantic proximity Read ↗

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.Semantic proximity Read ↗

Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients.Semantic proximity Read ↗

Multifocal desmoplastic medulloblastoma in an african-american child with nevoid basal cell carcinoma (gorlin) syndrome. Case report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.