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Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.

Cancer research - 15 Jun 1997

Xie J, Johnson R L, Zhang X, Bare J W, Waldman F M, Cogen P H, Menon A G, Warren R S, Chen L C, Scott M P, Epstein E H

Abstract excerpt

Patients with basal cell nevus syndrome have a high incidence of multiple basal cell carcinomas, medulloblastomas, and meningiomas. Because somatic PATCHED (PTCH) mutations have been found in sporadic basal cell carcinomas, we have screened for PTCH mutations in several types of sporadic extracutaneous tumors. We found that 2 of 14 sporadic medulloblastomas bear somatic nonsense mutations in one copy of the gene...

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PMID: 9192811

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Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.PMID 9192811Read ↗

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

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