Article
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 1997
Asada H, Kawamura Y, Maruyama K, Kume H, Ding R G, Kanbara N, Kuzume H, Sanbo M, Yagi T, Obata K
Abstract excerpt
In addition to its role as an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) is presumed to be involved in the development and plasticity of the nervous system. GABA is synthesized by glutamic acid decarboxylase (GAD), but the respective roles of its two isoforms (GAD65 and 67) have not been determined. The selective elimination of each GAD isoform by gene targeting is expected to clarify these...
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