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Article

Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997

Kash S F, Johnson R S, Tecott L H, Noebels J L, Mayfield R D, Hanahan D, Baekkeskov S

Abstract excerpt

gamma-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian brain, is synthesized by two glutamate decarboxylase isoforms, GAD65 and GAD67. The separate role of the two isoforms is unknown, but differences in saturation with cofactor and subcellular localization suggest that GAD65 may provide reserve pools of GABA for regulation of inhibitory neurotransmission. We have disrupted the...

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Identifiers

PMID: 9391152
DOI: 10.1073/pnas.94.25.14060
PMCID: PMC28432

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