Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GABA and histogenesis in fetal and neonatal mouse brain lacking both the isoforms of glutamic acid decarboxylase.

Neuroscience research - 1 Mar 1999

Ji F, Kanbara N, Obata K

Abstract excerpt

Recent in vitro investigations have suggested that GABA is involved in the development of the mammalian central nervous system. To evaluate the roles of GABA in neurogenesis in vivo, we generated mice lacking both the isoforms of glutamic acid decarboxylase (GAD), GAD65 and GAD67, by mating GAD65- and GAD67-mutant mice generated by homologous recombination in this laboratory. Similar to GAD67-deficient mice, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Brain
Share to Fetus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to gamma-Aminobutyric Acid

Share to Glutamate Decarboxylase

Share to Isoenzymes

Share to Mice, Knockout

Share to Ornithine Decarboxylase

Source

Identifiers

PMID: 10211762
DOI: 10.1016/s0168-0102(99)00011-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GABA and histogenesis in fetal and neonatal mouse brain lacking both the isoforms of glutamic acid decarboxylase.PMID 10211762Read ↗

Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase.Semantic proximity Read ↗

Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.Semantic proximity Read ↗

Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.Semantic proximity Read ↗

Gastrointestinal phenotype of GAD67lacZ transgenic mice with early postnatal lethality.Semantic proximity Read ↗

Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP miceSemantic proximity Read ↗

Development of the GABAergic phenotype in murine spinal cord-dorsal root ganglion cultures.Semantic proximity Read ↗

Nonneuronal expression of the GABA(A) beta3 subunit gene is required for normal palate development in mice.Semantic proximity Read ↗

Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice.Semantic proximity Read ↗

GAD and GABA in an enriched population of cultured GABAergic neurons from rat cerebral cortex.Semantic proximity Read ↗

Role of the GABA(A) receptor gamma2 subunit in the development of gonadotropin-releasing hormone neurons in vivo.Semantic proximity Read ↗

Retinal ganglion cell depletion alters the phenotypic expression of GABA and GAD in the rat retina.Semantic proximity Read ↗

Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.