Article
[Insulin resistance. Receptor and post-receptor abnormalities].
Minerva endocrinologica - 1 Jun 1998
Liguori M, Urso R, Fatigante G
Abstract excerpt
Insulin action starts with binding to a membrane receptor (insulin receptor-tyrosine kinase) and with activating an insulin receptor substrate 1 (IRS-1) and substrate 2 (IRS-2). Insulin receptors interact at least with three cascade reactions, phosphorylating G proteins and IRS-1, that activate P...
Topics
- Diabetes Mellitus, Type 2
- Dose-Response Relationship, Drug
- Enzyme Activation
- Humans
- Hyperglycemia
- Hypoglycemic Agents
- Insulin
- Insulin Resistance
- Muscle, Skeletal
- Mutation
- Obesity
- Phosphorylation
- Receptor, Insulin
- Signal Transduction