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Article

Assessing Rat Forelimb and Hindlimb Motor Unit Connectivity as Objective and Robust Biomarkers of Spinal Motor Neuron Function.

Scientific reports - 13 Nov 2019

Harrigan Markus E, Filous Angela R, Tosolini Andrew P, Morris Renee, Schwab Jan M, Arnold W David

Abstract excerpt

Sensitive and objective biomarkers of neuronal injury, degeneration, and regeneration can help facilitate translation of experimental findings into clinical testing. Whereas measures of upper motor neuron connectivity have been readily established, functional assessments of lower motor neuron (LMN) innervation of forelimb muscles are lacking. Compound muscle action potential (CMAP) and motor unit (MU) number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31723233
DOI: 10.1038/s41598-019-53235-w
PMCID: PMC6853930

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SOD1

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