Article
Analysis of HIV-2 RT mutants provides evidence that resistance of HIV-1 RT and HIV-2 RT to nucleoside analogs involves a repositioning of the template-primer.
Journal of molecular biology - 9 May 1997
Perach M, Rubinek T, Hughes S H, Hizi A
Abstract excerpt
Mutations that confer resistance to nucleoside analogs do not cluster around the deoxynucleotide triphosphate (dNTP) binding site. Instead, these mutations appear to lie along the groove in the enzyme where the template-primer binds. Based on such structural data and on complementary biochemical...
Topics
- DNA Primers
- DNA, Viral
- Deoxyguanine Nucleotides
- Deoxyribonucleotides
- Dideoxynucleotides
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1
- HIV-2
- Humans
- Models, Molecular
- Mutation
- RNA-Directed DNA Polymerase
- Recombinant Proteins
- Reverse Transcriptase Inhibitors
- Templates, Genetic
- Thymine Nucleotides