The response of renal plasma flow to angiotensin II infusion in a population-based sample and its association with the parental history of essential hypertension.

Abstract excerpt

BACKGROUND: Results from previous studies suggested that a blunted response of renal plasma flow (RPF) to angiotensin II infusion during a high-sodium diet (a phenotype associated with nonmodulation) is an intermediate phenotype for essential hypertension. OBJECTIVE: To determine whether RPF traits used to investigate nonmodulation have the characteristics of intermediate traits when examined in a...

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