Article
Glutamine synthetase and heteroresistance in methicillin-resistant Staphylococcus aureus.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1996
Strandén A M, Roos M, Berger-Bächi B
Abstract excerpt
Inactivation of femC in methicillin-resistant Staphylococcus aureus (MRSA) results in lowered methicillin resistance and a reduction in the amidation of the iso-D-glutamate of the peptidoglycan stem peptide. The femC phenotype is due to insertional inactivation of the glutamine synthetase repressor gene glnR by Tn551, which has a polar effect on glutamine synthetase (glnA) transcription. The complete glutamine...
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