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Article

Lack of expression of E-cadherin is associated with dissemination of Langerhans' cell histiocytosis and poor outcome

1 Mar 1997

Abstract excerpt

Langerhans' cell histiocytosis (LCH) often occurs in children as a cutaneous disease. The course of the disease is characterized by either spontaneous resolution or multivisceral dissemination with poor prognosis. The pathogenesis of LCH is not known. Since E-cadherin mediates homophilic adhesion of normal Langerhans' cells to keratinocytes and is also a ligand of the alpha E beta 7 intraepithelial lymphocyte...

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Identifiers

PMID: 9155716
DOI: 10.1002/(sici)1096-9896(199703)181:3<301::aid-path779>3.0.co;2-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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