[Apolipoprotein E epsilon 4 allel frequencies, plasma alpha 2-macroglobulin and plasminogen activator inhibitor 1 levels in residents of a rural area in Gunma prefecture].

Abstract excerpt

The apolipoprotein E4 (apoE4) epsilon 4 allele is a major riks factor for Alzheimer's disease. However, epsilon 4 is neither a necessary nor a sufficient condition for the development of this disease, and many cognitively healthy elderly people carry the epsilon 4 allele. To look for age-dependent changes in epsilon 4 allele frequencies in the general population, we measured the frequencies in 141 normal healthy...

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