Article
Combined molecular biological and molecular cytogenetic analysis of genomic changes in 146 patients with B-cell chronic lymphocytic leukemia.
Neoplasma - 1 Jan 2008
Berkova A, Pavlistova L, Babicka L, Houskova L, Tajtlova J, Balazi P, Cmunt E, Schwarz J, Karban J, Trneny M, Brezinova J, Zemanova Z, Michalova K
Abstract excerpt
Interphase fluorescence in situ hybridization was used to detect common deletions in B-CLL patients as well as trisomy 12 and aberrations of IgH gene complex at 14q32.33 where we evaluated not only translocation-like signal pattern but also deletions. 120 (82%) patients showed genetic changes - del(13)(q14) 95 (62%), deletion of ATM gene 22 (15%), deletion of p53 gene 25 (17%) and trisomy 12 was proved in 18...
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