Article
Spontaneous occurrence of early region 1A reiteration mutants of type 5 adenovirus in persistently infected human T-lymphocytes.
Virology - 14 Apr 1997
Tang Q, Lundholm-Beauchamp U, Ginsberg H S
Abstract excerpt
Mutants of type 5 adenovirus (Ad5) with reiterated DNA sequences in the E1a region appeared in a human T-lymphocyte cell line, Molt-4, persistently infected with H5sub304, a deletion/substitution mutant that has a wild-type phenotype in viral replication. Endonuclease analyses and DNA sequencing...
Topics
- Adenovirus E1A Proteins
- Adenoviruses, Human
- DNA, Viral
- Deoxyribonucleases, Type II Site-Specific
- HeLa Cells
- Humans
- Multigene Family
- Mutation
- RNA, Messenger
- RNA, Viral
- Sequence Analysis, DNA
- T-Lymphocytes
- Tumor Cells, Cultured
- Virus Latency