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Article

Spontaneous occurrence of early region 1A reiteration mutants of type 5 adenovirus in persistently infected human T-lymphocytes.

Virology - 14 Apr 1997

Tang Q, Lundholm-Beauchamp U, Ginsberg H S

Abstract excerpt

Mutants of type 5 adenovirus (Ad5) with reiterated DNA sequences in the E1a region appeared in a human T-lymphocyte cell line, Molt-4, persistently infected with H5sub304, a deletion/substitution mutant that has a wild-type phenotype in viral replication. Endonuclease analyses and DNA sequencing revealed DNA reiteration in each mutant. In the four representative mutants investigated, the DNA reiterations all...

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Identifiers

PMID: 9143284
DOI: 10.1006/viro.1997.8482

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