Article
Transforming growth factor α transforms astrocytes to a growth-supportive phenotype after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Oct 2011
White Robin E, Rao Meghan, Gensel John C, McTigue Dana M, Kaspar Brian K, Jakeman Lyn B
Abstract excerpt
Astrocytes are both detrimental and beneficial for repair and recovery after spinal cord injury (SCI). These dynamic cells are primary contributors to the growth-inhibitory glial scar, yet they are also neuroprotective and can form growth-supportive bridges on which axons traverse. We have shown that intrathecal administration of transforming growth factor α (TGFα) to the contused mouse spinal cord can enhance...
Topics
- Analysis of Variance
- Animals
- Astrocytes
- Axons
- Bromodeoxyuridine
- Cell Movement
- Cell Proliferation
- Cell Transdifferentiation
- Cells, Cultured
- Disease Models, Animal