Article
Regulation of heme biosynthesis in Salmonella typhimurium: activity of glutamyl-tRNA reductase (HemA) is greatly elevated during heme limitation by a mechanism which increases abundance of the protein.
Journal of bacteriology - 1 May 1997
Wang L Y, Brown L, Elliott M, Elliott T
Abstract excerpt
In Salmonella typhimurium and Escherichia coli, the hemA gene encodes the enzyme glutamyl-tRNA reductase, which catalyzes the first committed step in heme biosynthesis. We report that when heme limitation is imposed on cultures of S. typhimurium, glutamyl-tRNA reductase (HemA) enzyme activity is...
Topics
- Acclimatization
- Aldehyde Oxidoreductases
- Bacterial Proteins
- Cloning, Molecular
- Escherichia coli
- Genotype
- Heme
- Homeostasis
- Intramolecular Transferases
- Porphyrins
- Recombinant Fusion Proteins
- Salmonella typhimurium
- Substrate Specificity
- beta-Galactosidase