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Article

Cnr protein, the negative regulator of bacteriophage P4 replication, stimulates specific DNA binding of its initiator protein alpha.

Journal of bacteriology - 1 May 1997

Ziegelin G, Calendar R, Ghisotti D, Terzano S, Lanka E

Abstract excerpt

Bacteriophage P4 DNA replication depends upon the phage-encoded alpha protein, which has DNA helicase and DNA primase activity and can specifically bind to the replication origin (ori) and to the cis replicating region (crr). The P4 Cnr protein functions as a negative regulator of P4 replication, and P4 does not replicate in cells that overexpress cnr. We searched for P4 mutants that suppressed this phenotype...

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Identifiers

PMID: 9139894
DOI: 10.1128/jb.179.9.2817-2822.1997
PMCID: PMC179040

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