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Article

Lambda gpP-DnaB Helicase Sequestration and gpP-RpoB Associated Effects: On Screens for Auxotrophs, Selection for Rif(R), Toxicity, Mutagenicity, Plasmid Curing.

Viruses - 22 Jun 2016

Hayes Sidney, Wang Wen, Rajamanickam Karthic, Chu Audrey, Banerjee Anirban, Hayes Connie

Abstract excerpt

The bacteriophage lambda replication initiation protein P exhibits a toxic effect on its Escherichia coli (E. coli) host, likely due to the formation of a dead-end P-DnaB complex, sequestering the replicative DnaB helicase from further activity. Intracellular expression of P triggers SOS-independent cellular filamentation and rapidly cures resident ColE1 plasmids. The toxicity of P is suppressed by alleles of P...

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Identifiers

PMID: 27338450
DOI: 10.3390/v8060172
PMCID: PMC4926192

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Source receipt: pubmed, retrieved 7 Sept 2026.

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