Article
Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine.
The EMBO journal - 17 Mar 1997
White R, Sjöberg M, Kalkhoven E, Parker M G
Abstract excerpt
The oestrogen receptor is a member of the nuclear receptor family of transcription factors which, on binding the steroid hormone 17beta-oestradiol, interacts with co-activator proteins and stimulates gene expression. Replacement of a single tyrosine in the hormone-binding domain generated activated forms of the receptor which stimulated transcription in the absence of hormone. This increased activation is related...
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