Article
The novel UGT1 gene complex links bilirubin, xenobiotics, and therapeutic drug metabolism by encoding UDP-glucuronosyltransferase isozymes with a common carboxyl terminus.
Journal of pharmacokinetics and biopharmaceutics - 1 Oct 1996
Owens I S, Ritter J K, Yeatman M T, Chen F
Abstract excerpt
The UDP-glucuronosyltransferase system (transferase) plays an important role in the pharmacokinetics of clearance of endogenous metabolites, therapeutic drugs, and xenobiotics. The human bilirubin and phenol transferases are encoded by the same gene complex which we designate UGT1. The gene arran...
Topics
- Animals
- Cloning, Molecular
- Crigler-Najjar Syndrome
- DNA
- Female
- Genotype
- Gilbert Disease
- Glucuronosyltransferase
- Humans
- Hyperbilirubinemia, Hereditary
- Male
- Molecular Sequence Data
- Pharmaceutical Preparations
- Phenotype
- RNA
- Rats
- Rats, Gunn
- Xenobiotics