Article
A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase.
The Journal of biological chemistry - 5 Nov 1993
Ritter J K, Yeatman M T, Kaiser C, Gridelli B, Owens I S
Abstract excerpt
The characterization (Ritter, J. K., Chen, F., Sheen, Y. Y., Tran, H. M., Kimura, S., Yeatman, M. T., and Owens, I. S. (1992) J. Biol. Chem. 267, 3257-3261) of the single-copy UGT1 gene complex encoding both bilirubin and phenol UDP-glucuronosyltransferases (transferase) has been critical to the...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Codon
- Crigler-Najjar Syndrome
- DNA Primers
- Female
- Glucuronosyltransferase
- Humans
- Hydrogen-Ion Concentration
- Male
- Microsomes, Liver
- Molecular Sequence Data
- Phenylalanine
- Rats
- Sequence Alignment
- Sequence Deletion