Article
The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes.
Pharmacogenetics - 1 Jun 1992
Owens I S, Ritter J K
Abstract excerpt
At least three types of congenital nonhemolytic unconjugated hyperbilirubinemias, including the rare Crigler-Najjar (CN) diseases (Types I or II) and Gilbert's syndrome (affecting 6% of the population) are associated with either absent or reduced hepatic UDP-glucuronosyltransferase (transferase) activity towards the potentially toxic endogenous acceptor, bilirubin. Here, we review the biochemical studies...
Topics
- Animals
- Cloning, Molecular
- Crigler-Najjar Syndrome
- DNA
- Female
- Gilbert Disease
- Glucuronosyltransferase
- Humans
- Hyperbilirubinemia, Hereditary
- Male
- Multigene Family