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Article

Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production.

European journal of immunology - 1 Apr 1997

Beutner U, Launois P, Ohteki T, Louis J A, MacDonald H R

Abstract excerpt

An unusual subset of mature T cells expresses natural killer (NK) cell-related surface markers such as interleukin-2 receptor beta (IL-2R beta; CD122) and the polymorphic antigen NK1.1. These "NK-like" T cells are distinguished by their highly skewed V alpha and V beta repertoire and by their ability to rapidly produce large amounts of IL-4 upon T cell receptor (TCR) engagement. The inbred mouse strain SJL (which...

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PMID: 9130646
DOI: 10.1002/eji.1830270419

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