Article
Phenotypic heterogeneity, novel diagnostic markers, and target expression profiles in normal and neoplastic human mast cells.
Best practice & research. Clinical haematology - 1 Sept 2010
Valent Peter, Cerny-Reiterer Sabine, Herrmann Harald, Mirkina Irina, George Tracy I, Sotlar Karl, Sperr Wolfgang R, Horny Hans-Peter
Abstract excerpt
Mast cells (MC) are specialized immune cells that play a key role in anaphylactic reactions. Growth, differentiation, and function of these cells are regulated by a complex network of cytokines, surface receptors, signaling molecules, the microenvironment, and the genetic background. A number of previous and more recent data suggest that MC are heterogeneous in terms of cytokine-regulation, expression of...
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